Yeast genes and human disease

Article Abstract:

Saccharomyces cerevisiae genes are useful in determining the role of genes that are mutated in human disease forms. The role of the human ATM gene has been revealed from a study of yeast genes, such as MEC1 and TEL1. Almost 70% of the S. cerevisiae genome sequence is available on public databases. The sequence will permit cross-species connections and help human disease research. A study of the relationship between model organization genes and genes mutated in diseases will help in identifying new genes associated with diseases.

Usage, Diseases, Mutation (Biology), Mutation, Yeast, Yeast (Food product)

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Complementation of the DNA repair defect in xeroferma pigmentosum group G cells by a human cDNA related to yeast RAD2

Article Abstract:

Frog and human complementary DNAs (cDNA) were isolated to determine their roles in the DNA repair pathway. Expression of the human cDNA restored ultraviolet sensitivity and unscheduled DNA synthesis of lymphoblastoid cells in xeroderma pigmentosum (XP-G) cells. These results did not emerge in Cockayne's syndrome cells since a different protein is responsible for the defect.

Genetic aspects, DNA repair, Xeroderma pigmentosum, Antisense DNA

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