p25 protein in neurodegeneration

Article Abstract:

Research indicating that the amount of p25, an abnormal truncated form of p35, a regulatory subunit of the protein kinase Cdk5, in the frontal cortex of patients with Alzheimer's disease or Down's syndrome is lower than in controls is discussed. This contradicts earlier research, and also suggests that this protein has been downregulated in these patients.

Alzheimer's disease, Protein kinases

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Human chromosome 21: landmarks in chromosome sequencing

Article Abstract:

A poster is presented which describes the landmarks which occurred from 1990 to 2000 in the sequencing of human chromosome 21. The techniques used to determine the make up of the chromosome are discussed.

History, Genetic aspects, Human beings, Chromosome mapping, Humans

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The DNA sequence of human chromosome 21

Article Abstract:

The article maps out the sequence of human chromosome 21, which is responsible for the occurrence of Down Syndrome if three chromosome 21s exist instead of the normal 2.

Identification and classification, Chromosomes, DNA sequencers

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