Traits that influence longevity in mice: a second look

Article Abstract:

An analysis of genetic factors affecting longevity in mice indicates that interactions between loci affect life span. Moreover, viral infections and other environmental factors may alter the course of allelic interactions. Genetic interactions in both homozygous and heterozygous F2 hybrid mice were studied through cluster analysis. The study shows that dilute brown female mice have shorter life spans than other females while male H-2b/H-2b mice, excluding dilute brown and dilute brown H-2b/H-2d, have shorter life spans than other males.

Genetic aspects, Longevity, Age (Biology)

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Identification of hepatocarcinogen-resistance genes in DBA 2 mice

Article Abstract:

Experimental studies of BXD recombinant inbred mice and D2B6F1 X B6 backcross and D2B6F2 intercross mice treated at 12 days of age with live tumors and N,N-diethylnitrosamine help examine the genetic regulation of hepatocarcinogenesis in DBA 2J mice. Experimental data suggest that two genes, Hcr1 and Hcr2 in D2 mice significantly reduce the susceptibility to liver tumor induction and these genes are mapped to chromosomes 4 and 10 respectively. Variance in the backcross population is determined by these resistance loci Hcr1 and Hcr2.

Research, Diseases, Liver cancer, Natural immunity

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Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent

Article Abstract:

Three statistical models for linkage analysis of complex traits are evaluated. The models assumed identity by descent for genetic relations and avoided candidate genes to create an extensive genome field. The multilocus models involved were the single locus search, simultaneous search and conditional search. These methods have assumed additive and multiplicative properties of earlier linkage models.

Models, Statistics, Statistics (Data), Linkage (Genetics)

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