Barriers to translocation of organic ions in phospholipid membranes

Article Abstract:

The translocation of organic ions across phospholipid bilayer membranes is restricted by a dominant barrier located between the 'polar region' and the 'nonpolar region' of the membrane layer has been studied. Carbonyl cyanide m-chlorophenylhydrazone (CCCP-) is used as the organic anion in the research while soybean phospholipid vesicles in aqueous solutions are treated as model membrane systems. Results show the rate of decay of the pH difference across the soybean membranes increases substantially when the substep was catalyzed. The CCCP- ion translocation has an alternate path for the compensating charge flux of alkali metal ions.

Analysis, Ions, Lipid membranes, Ionic mobility, Bilayer lipid membranes, Ion migration

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Static and kinetic investigations of the structural ordering of phospholipid membranes doped with azobenzene derivative

Article Abstract:

Research was conducted to examine the structural ordering of phospholipid membranes doped with azobenzene derivative by static and kinetic experiments. A fatty acid derivative was incorporated into large unilamellar vesicles of L-alpha-dimyristoylphosphatidylcholine. Stopped-flow light scattering measurements were carried out to study its effects before and after photoisomerization on fast osmotic processes. Results demonstrate that static and kinetic analyses allow a better knowledge of the effect of doping and photoisomerization on the structural ordering of the lipid membranes.

Fatty acids, Isomerization

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Interaction of a peptide from the pre-transmembrane domain of the severe acute respiratory syndrome coronavirus spike protein with phospholipid membranes

Article Abstract:

The studies about the severe acute respiratory syndrome coronavirus (SARS-CoV) that envelope Spike glycoprotein, a Class I viral fusion protein are presented. The results provide insight into fusion process which might be essential for the assistance and enhancement of viral and cell fusion.

Physiological aspects, Technology application, Infrared spectroscopy, Adenoviruses, Human, Human adenoviruses, Viral proteins, Chemical properties

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