Filamentous phage display in the new millennium
Article Abstract:
The use of the filamentous bacteriophage M13 and its close relative fd, peptides and proteins that are displayed on the surface of other bacteriophages and eukaryotic viruses are reviewed. Phage could be introduced into the animal's system through a number of means including injection, ventilation and gavage, and after a brief time period, tissue biopsies are collected, homogenized, and used to infect bacteria for phage amplification and subsequent rounds of selection.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
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2-deoxystreptamine: Central scaffold of aminoglycoside antibiotics
Article Abstract:
A key feature of the aminoglycoside antibiotics is a 1,3-diaminocyclohexanetriol termed as streptamine or, in cases where the 1-hydroxy function is deoxygenated as in most aminoglycosides, 2-deoxystreptamine. In general, aminoglycosides show a strong synergistic effect upon coadministration with penicillin, a particularly useful combination for treatment of patients with infections of unknown origin.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
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Syntheses around the transglycosylation step in peptidoglycan biosynthesis
Article Abstract:
The total syntheses of lipid II and analogues, which are acceptor substrates of the transglycolases and of compounds that interfere with the transglycosylation reaction, are described. The transglycolases involved in peptidoglycan biosynthesis are promising targets for new anti-infectives and their synthesis would help in understanding their structure and their role as antibiotic.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
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