Commentary

Article Abstract:

Research has provided strong evidence for the idea that the genes that regulate cell cycle progression and apoptosis are also involved in the aging process. The paper of Barnes, Covington and Lee (1999) on age-related changes in apoptosis takes this idea further and tries to establish a link between the pace of aging and calorie intake. While their results provide new insights into germ cell apoptosis and its diet-related determinants, further research is needed before the link between testicular apoptosis and aging can be determined conclusively.

Physiological aspects, Testis, Cell death, Nutrition, Germ cells, Rats as laboratory animals, Laboratory rats

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Author's response to commentary

Article Abstract:

John E. Morley and associates suggested in their comments on a study on the relationship between aging and leptin levels that increased leptin may be responsible for the decrease of relative visceral adiposity in aging. They also proposed that leptin may be a possible candidate hormone for anorexia development in aging. However, it must be noted that separating insulin influence from that of leptin is difficult to do which may hamper studies on the concept suggested by Morley.

Criticism and interpretation, Leptin, Longevity, Insulin, Fat, Fats, Morley, John E.

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