Risk factors for hospitalized gastrointestinal bleeding among older persons

Article Abstract:

This article examines risk factors associated with gastrointestinal bleeding among adults over the age of sixty-five. Findings indicate that advanced age, being unmarried, male gender, reliance on multiple medications, cardiovascular disease, and difficulty with daily activities are associated with an increased risk of hospitalization for gastrointestinal bleeding.

Author: Koepsell, Thomas D., Furberg, Curt D., Kaplan, Robert C., Psaty, Bruce M., Heckbert, Susan R., Polack, Jospeh F., Schoen, Robert E.
Health aspects, Aged, Elderly, Statistical Data Included, Drugs, Cardiovascular diseases, Risk factors, Gastrointestinal bleeding, Gastrointestinal hemorrhage, Sex differences, Marital status

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Weight loss, muscle strength, and angiotensin-converting enzyme inhibitors in older adults with congestive heart failure or hypertension

Article Abstract:

The relation between angiotensin-converting enzyme inhibitor use and weight maintenance and muscle strength is examined. Congestive heart failure, hypertension, aging, etc. are discussed.

Author: Furberg, Curt D., Psaty, Bruce M., Smith, Nicholas L., Heckbert, Susan R., Lumley, Thomas, Lyles, Mary F., Schellenbaum, Gina D., Rea, Thomas D.
Science & research, Aging, ACE inhibitors, Angiotensin converting enzyme inhibitors, Weight loss, Aging (Biology)

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Assessment and control for confounding by indication in observational studies

Article Abstract:

In pharmaceutical research and evaluation of pharmacologic therapies, assessment and control for confounding by indication in observational studies. IF clinical trial results cannot be achieved, the alternative is observational epidemiologic investigation. After adjustment for known risk factors, residual confounding may be present. Residual confounding is hard to exclude, but knowledge of methods to detect and control it make it possible to assess claims that confounding is an explanation for findings.

Author: Koepsell, Thomas D., Rosendaal, Frits R., Weiss, Noel S., Furberg, Curt D., Pahor, Marco, Psaty, Bruce M., Siscovick, David S., Lin, Danyu
Standards, Planning, Experimental design, Research design, Pharmaceutical research

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Subjects list: Research, United States
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