A C. elegans model of nicotine-dependent behavior: Regulation by TRP-family channels

Article Abstract:

A C. elegans model of nicotine-dependent behavior is developed, which shows that worms display behavioral responses to nicotine that parallel those observed in mammals, including acute response, tolerance, withdrawal and sensitization. The results have shown that C. elegans can be used to characterize known genes as well as to identify new genes regulating nicotine responses.

DNA binding proteins, Nicotinic receptors, Report

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FOS-1 promotes basement-membrane removal during anchor-cell invasion in C.elegans

Article Abstract:

The fos transcription factor ortholog fos-1 was identified as a critical regulator of basement-membrane removal. The results reveal a key genetic network that controls basement-membrane removal during cell invasion.

Genetic transcription, Transcription (Genetics), Cell membranes, Genetic research

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