A bifunctional O-GlcNAc transferase governs flagellar motility through anti-repression

Article Abstract:

The first bacterial O-linked N-acetylglucosamine transferase (OGT) is identified that is specific for a prokaryotic protein as GmaR, a DegU-regulated flagellin glycosyltransferase that mediates [beta]-O-linked GlcNAc modification of flagellin (FlaA) in Listeria monocytogenes. The results have established GmaR as the first known example of a bifunctional protein that transcriptionally regulates expression of its enzymatic substrate.

Genetic aspects, Flagella (Microbiology), Flagella, Listeria monocytogenes, Genetic research

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Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural development

Article Abstract:

Results show that early expression of wnt8 and associated genes besides inducing synthesis of neural-specific markers also inhibit Bmp4 expression in Xenopus. Data further indicate that wnt8 encoded protein Wnt8 inhibits Bmp4 expression at early stages of gastrulation.

United Kingdom, United States, Statistical Data Included, Research, Cellular signal transduction, Gene expression, Developmental neurology, Nerve tissue

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