Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

Article Abstract:

A study was conducted to identify TXB181, which was characterized as the human homolog of yeast mitotic checkpoint MAD1 protein (HsMAD1), as the target of the human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax. HsMAD1 functions as a homodimer which localizes to the centrosome during metaphase and to the spindle midzone and the midbody during anaphase and telephase stages. It was observed that expression of either Tax or a transdominant-negative TXBP181 results in multinucleated cells, a phenotype consisttent with a loss of HsMAD1 function.

Physiological aspects, HTLV (Viruses), HTLV viruses

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Protein-protein contacts that activate and repress prokaryotic transcription

Article Abstract:

The mechanistic consequences of protein-protein contacts that activate and repress prokaryotic transcription are discussed. The transcription initiation has been influenced by in vitro studies wherein RNA polymerase recognizes and binds to double-stranded promoter DNA to form a closed complex. RNA polymerase directly promotes the synthesis of short abortive products while escaping from the promoter by breaking contacts that stabilize the open complex.

Prokaryotes, RNA polymerases

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