Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1

Article Abstract:

The expression of the Wilms' tumor gene-1, 'Wt1', in coronary vessels, which could contribute to the defective cardiac vascularization in 'Wt1' mice is studied. It is found that transcriptional activation of the TrkB neurotrophin receptor gene by the Wilms' tumor suppressor 'Wt1' is a crucial mechanism for normal vascularization of the developing heart.

United States, Genetic transcription, Transcription (Genetics), Nephroblastoma, Coronary vessels

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Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: Implications for alveolar rhabdomysarcoma cell of origin

Article Abstract:

A Cre-mediated conditional knock-in of Pax3:Fkhr was generated into the mouse Pax3 locus to investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas. Findings suggest that mature differentiating skeletal muscle and not satellite cells gives rise to alveolar rhabdomyosarcomas.

Translocation (Genetics), Genetic research, Translocations (Genetics)

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