Assembly of an active translation initiation factor complex by a viral protein

Article Abstract:

A study is presented to establish that the herpes simplex virus-1 (HSV-1) ICP6 polypeptide associates with eIF4G, the cap-binding protein, to promote eIF4F complex assembly. The factors which are capable of interacting with eIF4G and promoting eIF4G complex assembly may play important roles in a variety of processes where translation complexes need to be remodeled or assembled on populations of newly synthesized or derepressed mRNAs.

Polypeptides, Herpes simplex virus, Genetic translation, Translation (Genetics), Viral genetics, Chemical properties

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Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures

Article Abstract:

The checkpoint mediator protein Claspin is indespensable for the ATR-dependent phosphorylation of Chk1 in response to stalled DNA replication forks in Xenopus egg extracts. Site-specific phosphorylation of a checkpoint mediator protein is a crucial determinant in the discrimination between various checkpoint-inducing structures.

Xenopus

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Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiscent cells.

Article Abstract:

A study on contribution of translation initiation factor, eIF4E, phosphorylation in herpes simplex virus-1(HSV-1) growth is conducted. The results reveal that phosphorylation of eIF4E by mnk-1 is critical for viral protein synthesis and replication.

Herpesvirus diseases, Herpesvirus infections, Herpes

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