Bacterial disease in diverse hosts

Article Abstract:

The developement of new assays and technologies have allowed researchers to genetically manipulate the host to examine several hypotheses about virulence factor and host resistance mechanisms. Several studies on bacteria diseases were able to reveal that some pathogens can produce common virulence factors that cause disease in diverse hosts such as plants, animals and nematodes. One of these is the human pathogen Pseudomonas aeruginosa that was found to produce common virulence factors that cause disease in the plant Arabidopsis thaliana plant and in the nematode Caenorhabditis elegans.

Bacterial infections, Host-bacteria relationships, Pseudomonas aeruginosa, Virulence (Microbiology), Pathogenic microorganisms

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Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells

Article Abstract:

The role of enteropathogenic E. coli (EPEC) receptor for outer membrane protein, Hp90, was established through PAGE-blotting of EPEC-infected HeLa cells. Results revealed that Hp90 was in fact, a bacterial protein (Tir). Its delivery to the host cell was mediated by the type III-secreted products EspA and EspB and then functions as the intimin receptor. A possible role of Tir tyrosine phosphorylation in intimin binding and pedestal formation was implicated.

Escherichia coli, Cell receptors, Mammals, Cell adhesion

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Anti-immunology: Evasion of the host immune system by bacterial and viral pathogens

Article Abstract:

Some of the many molecular mechanisms that bacterial and viral and pathogens use to evade host immune defenses are highlighted. The success of each pathogen is directly dependant on its ability to mount effective anti-immune response within the infected host, which can ultimately result in acute disease, chronic infection or pathogen clearance.

Genetic aspects, Virus diseases, Genetic research

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