Bacterial polysaccharides in sickness and in health

Article Abstract:

The various uses of bacterial polysaccharides and the gene cluster encoding them in Escherichia coli include biomedical and nonmedical applications. Polysaccharides are used as emulsion stabilizers, gelling agents, lubricants and paint thickeners. Their biomedical applications include their use as anticoagulants, substitutes for vitreous humour and in wound dressings. The capsules of the bacterial polysaccharides prevents them from drying and makes them resistant to the host's immune system. The group II capsule gene cluster of E. coli contains conserved regions 1 and 3 and an K antigen specific region 2.

Analysis, Usage, Microbial polysaccharides, Polysaccharides

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A chimaeric plant virus vaccine protects mice against a bacterial infection

Article Abstract:

Research was conducted to examine the vaccine potential of a plant virus, cowpea mosaic virus (CPMV), which was genetically engineered to express and display foreign peptides on its surface. The objective was to determine if vaccination using a chimaeric virus particle displaying a peptide obtained from the outer membrane protein F of Pseudomonas aeruginosa could provide protection from a bacterial infection. Results clearly suggest that the use of CMPV has several advantages over other P. aeruginosa vaccine candidates.

Research, Cowpea, Prevention, Bacterial infections, Plant viruses, Viral vaccines

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BacSim, a simulator for individual-based modelling of bacterial colony growth

Article Abstract:

An individual-based model called BacSim was developed to study cellular processes present in the microbial populations of Escherichia coli. The objective of the model was to assimilate the subcellular and biochemical processes into whole-cell models. BacSim simulated cells electronically as object instances of an object-oriented program. The model showed its capability in simulating bacterial population growth and microbial ecology.

Methods, Models, Escherichia coli, Microbial ecology, Simulation methods, Simulation, Microbial populations

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