CREB phosphorylation and dephosphorylation: a Ca2+- and stimulus duration-dependent switch for hippocampal gene expression

Article Abstract:

The signaling pathways that regulate the phosphorylation of cyclic adenosine monophosphate-responsive element binding protein (CREB) were analyzed in hippocampal neurons. CREB phosphorylation involving multiple Ca2+/calmodulin [CAM]-dependent kinases and phospho-CREB (pCREB) dephosphorylation was affected by synaptic activity in hippocampal neurons. Furthermore, nuclear protein phosphatase 1-mediated phosphorylation of nuclear pCREB is affected by the inactivation of CaN due to neuronal synaptic activity.

Carrier proteins, Transport proteins, Phosphorylation, Neural transmission, Synaptic transmission, Hippocampus (Brain)

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Thy-1, the enigmatic extrovert on the neuronal surface

Article Abstract:

Thy-1 is a glycoprotein with a characteristic immmunoglobulin variable domain fold attached to the plasma membrane by glycophosphatidylinositol anchors. It was the first lymphocyte surface antigen shown to be restricted to a functional subset of lymphocytes. Current research on the nervous system suggest that neuronal Thy-1 interacting with astrocyte restricts axonal growth. However, despite numerous findings on the nature of Thy-1, defining its functions remains to be accomplished.

Research, Glycoproteins, Antigens

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Splicing regulation in neurons: tinkering with cell-specific control

Article Abstract:

Neurons are characterized by regulated alternative splicing events that result in protein structural changes. The neural specificity of the splicing activity promotes the selection of neuron-specific axon and differences in the level of repressor machineries. Moreover, the balance of regulation can be controlled from one cell type to another by differences in the interaction regulatory factors. Opposing signals also permit positive and negative control mechanisms to be overlaid.

Analysis, Genetic engineering, Proteins, Protein structure

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