GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs

Article Abstract:

The stimulatory effect of yeast protein Rcn1 that involves phosphorylation of a conserved serine residue by Mck 1, a member of the GSK-3 family of protein kinases is shown. Accordingly, the findings demonstrate that calcineurin signaling can be significantly modulated by GSK-3 through effects on RCNs and provide new opportunities for the therapeutic control of calcineurin.

Science & research, Phosphorylation, Yeast fungi, Yeasts (Fungi), Genetic research, Calcineurin

---

A conserved family of calcineurin regulators

Article Abstract:

A conserved family of calcineurin regulators is discussed. A newly identified family of proteins conserved in fungi and animals inhibits calcineurin function if overexpressed. It was identified using a genetic screen in yeast. The Rcn1p family may act as regulators of feedback of calcineurin signaling. Various calcineurin-dependent functions may be affected in turn.

Fungi, Yeast, Yeast (Food product), Phosphatases, Calcium, Calcium (Chemical element)

---

Characterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing system

Article Abstract:

ATP-dependent U6 and U4 interactions with the 5' splice site have been characterized using a Saccharomyces cerevisiae in vitro trans-splicing system. The interactions are independent of ATP-mediated U2 association with the branch point.

Statistical Data Included, Protein crosslinking, RNA

Similar abstracts:

• Abstracts: Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle. Wnt signals from the neural tube block ectopic cardiogenesis
• Abstracts: MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Requirement of the JIP1 scaffold protein for stress-induced JNK activation
• Abstracts: Citrate synthase and 2-methylcitrate synthase: structural, functional and evolutionary relationships. 2-Oxoacid dehydrogenase multienzyme complexes in the halophilic Archaea?: gene sequences and protein structural predictions
• Abstracts: An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-2 cooperate to activate EGF receptor signaling
• Abstracts: The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. Control of her1 expression during zebrafish somitogenesis by a Delta-dependent oscillator and an independent wave-front activity

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.