Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

Article Abstract:

Defective neurogenesis resulting from DNA ligase IV deficiency has been found to require Atm according to this research communication. Ataxia telangiectasia is from mutations of ATM. Atm is necessary for apoptosis in all parts of the DNA ligase IV-deficient developing nervous system. ATM could be important for preventing accumulation of DNA-damaged cells in the nervous system that might in time lead to the neurodegeneration observed in ataxia telangiectasia.

DNA, Immunocytochemistry, Developmental neurology, Ataxia telangiectasia, Ligases

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Defective processing of methylated single-stranded DNA by E. coli alkB mutants

Article Abstract:

Processing of methylated single-stranded DNA by Escherichia coli alkB mutants and its defects are discussed. Data show alkB mutants have a marked defect in processing methylation damage in single-stranded DNA. AlkB may act on alkylated single-stranded DNA at transcribed regions or in replication forks. Stationary phase alkB cells were less methylmethanesulfonate (MMS)-sensitive than fast-growing cells, which supports that hypothesis.

Statistical Data Included, DNA repair, Escherichia coli, Methylation

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Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome

Article Abstract:

A heterozygous TREX1 mutation causing familial chilblain lupus is reported. TREX1 constitutes the major 3'->5' DNA exonuclease activity measured in mammalian cells.

Science & research, Causes of, Lupus, Exonucleases, Heterozygosis, Heterozygote, Aicardi syndrome, Report

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