Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

Article Abstract:

FoxO forkhead transcription factors are found to act as signal transducers at the meeting point of Smad, P13k and FoxG1 pathways and Smad proteins activated by Tgf-beta, a pleiotropic cytokine, form a complex with FoxO proteins to activate the growth inhibitory gene p21Cip1. Studies suggest that the activity of this network imparts resistance to the TGF-beta mediated cytostasis during the development of the telencephalic neuroepithelium and in glioblastoma brain tumor cells.

Pleiotropy

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The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

Article Abstract:

A study is conducted to show that condensin facilitates the removal of cohesin from chromosomes during the first meiotic division of budding yeast and that this removal is important to dissolve the links between homologs that ensure proper homolog segregation. This provides an example of a functional connection between cohesin and condensin, two different SMC complexes.

United States, Meiosis, Ubiquitin-proteasome system

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Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-(kappa)B signaling

Article Abstract:

Mice lacking Cyld are shown to be highly susceptible to chemically induced skin tumors. Data indicates that, depending on the external signals, Cyld can negatively regulate different NF-(kappa)B pathways, inactivation, while inhibition of Bcl-3 controls proliferation and tumor growth.

Oncogenes

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