Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

Article Abstract:

Results demonstrate that TIP60 histone acetylase possesses ATPase, DNA helicase, and DNA binding properties in addition to its important chromatin modifying activity. Data show that cells defective for DNA-break repair capability lack the histone acetylase activity leading to apoptotic machinery breakdown.

Japan, Cell death, DNA repair, Enzymes, Enzyme structure-activity relationships

---

The p400 complex is an essential E1A transformation target

Article Abstract:

Research has been conducted on the E1A binding protein complex. The identification of this complex which is essential for the E1A-mediated transformation has been carried out and the results are reported.

France, Statistical Data Included, Carrier proteins, Transport proteins, Cell research, Cytological research

---

Histone-like TAFs within the PCAF histone acetylase complex

Article Abstract:

Research was conducted to identify the existence of PCAF in a complex composed of more than 20 distinct polypeptides. Tests involving the purification of PCAF in its native state were performed. Results revealed that some of the polypeptides were observed to be similar to TBP-associated factors. In addition, the PCAF complex features several histone fold-containing factors.

Research, Polypeptides

Similar abstracts:

• Abstracts: Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
• Abstracts: Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. The Drosophila Shark tyrosine kinase is required for embryonic dorsal closure
• Abstracts: Activation of the IkB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
• Abstracts: Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
• Abstracts: Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.