KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
Article Abstract:
KCNQ4, a novel member of the KCNQ branch of the potassium channel gene family, was cloned to study its role in the inheritance of hearing loss in humans. Results showed that KCNQ4 maps to the DFNA2, a locus for dominant progressive hearing loss and is expressed in sensory outer hair cells in the cochlea. A mutation of the KCNQ4 gene in a DFNA2 pedigree was found to change a residue in the KCNQ4 pore region by eliminating the potassium currents of the wild-type KCNQ4.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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The stem cell concept in plants: a matter of debate
Article Abstract:
The author review the publications on stem cells in plants. The topics of interest include the definition of stem cells and their difference from other meristem cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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