Pten, tumorigenesis, and stem cell self-renewal

Article Abstract:

Self-renewal pathways crucial for maintaining stem cells are deregulated in cancer, raising the spectre that cancer therapies targeting such pathways might also ablate normal stem cell. Different self-renewal mechanisms for maintaining pools of leukemic stem cells and normal hematopoietic stem cells (HSCs) identified and it is shown that the deletion of the Pten tumor suppressor gene results in generation of leukemic stem cells but depletion of normal HSCs.

Tumor necrosis factor, Tumour necrosis factor

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Identification of Bronchioalveolar stem cells in normal lung and lung cancer

Article Abstract:

A regional pulmonary stem cell population, termed as bronchioalveolar stem cells (BASCs) is isolated and identified at the bronchioalveolar duct junction. Data support the hypothesis that BASCs are a stem cell population that maintains the bronchiolar Clara cells and alveolar cells of the distal lung and that their transformed counterparts give rise to adenocarcinoma.

Lung cancer, Genetic research

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Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

Article Abstract:

The p53 tumor is often altered in many human tumors through missense mutations that result in accumulation of p53 protein where the mutations confer dominant-negative or gain-of-function properties to p53. Studies were conducted to find out the physiological effects of p53 point mutation, the structural mutant as well as the contact mutant.

Suppression, Genetic, Tumor suppressor genes, Li-Fraumeni syndrome, Tumour suppressor genes, Suppressor mutation

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