Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis

Article Abstract:

Study done to analyze the effect of C6-HSL, C8-HSL, and C10-HSL cleavage on twitching and swarming motility, beta-hemolysis and carbon utilization by the expression of Bacillus sp. AiiA lactonases in B. thailandensis is reported. Findings of the study reveals that heterologous expression of Bacillus sp. AiiA lactonases in B. thailandensis reduced AHL accumulation, affected both swarming and twitching motility, increased generation time, altered substrate utilization and prevented the betahemolysis of sheep erythrocytes.

Gene expression, Erythrocytes, Red blood cells

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A quorum-quenching approach to investigate the conservation of quorum-sensing regulated functions within the Burkholderia cepacia complex

Article Abstract:

A broad-host-range plasmid that allowed the heterologous expression of the Bacillus sp. strain 240B1 AiiA lactonase which hydrolyzes the lactone ring of various AHL signal molecules in all described B. cepacia complex species is constructed. It is revealed that expression of AiiA abolished or greatly reduced the accumulation of AHL molecules in the culture supernatants of all tested Burkholderia cepacia complex strains.

Genetic aspects, Bacillus (Bacteria), Bacillus

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Caenorhabditis elegans senses bacterial autoinducers

Article Abstract:

A study examined whether Caenorhabditis elegans could sense the acylated homoserine lactone (AHSL) autoinducers produced by many gram-negative bacteria possessing quorum-sensing (QS) systems. Data indicates that Caenorhabditis elegans can distinguish AHSLs and could use them for mediating aversive or attractive learning.

United States, Gram-negative bacteria, Caenorhabditis elegans

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