Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types

Article Abstract:

A study was conducted to determine how transient gradients of signalling molecules cause the generation of specific cell types during mammalian organogenesis. Results suggest that the reciprocal interaction and the DNA binding-dependent and -independent actions of two transcription factors, namely, Pit1 and GATA2 provide the molecular memory that mediates gradient-induced determination of pituitary cell types.

Physiological aspects, Developmental cytology, Cell organelles, Organelles, Cell physiology

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Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development

Article Abstract:

Pitx1 gene-deleted mice have reciprocal abnormalities of one dorsal and two ventral anterior pituitary cell types. The abnormalities likely are based on its synergistic functions with other transcription factors and defects in the derivatives of the first brachial arch. The derivatives would includ cleft palate, which would suggest a proliferative defect analogous to that seen in the hindlimb.

United States, Cellular signal transduction, Morphogenesis

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Multistep signaling requirements for pituitary organogenesis in vivo

Article Abstract:

A ventral-to-dorsal gradient determines the pituitary cell types producing different hormones. An experiment produces in vivo and in vitro proof of the stages involved in the pituitary cell development. The signals that herald the different stages are listed. These cells play a critical role in enabling the pituitary gland to maintain homeostasis.

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