Reversing time: origin of telomerase

Article Abstract:

Telomerases is a ribonucleoprotein that contains an RNA template. Telomerase solutions are the most widespread and possibly the oldest among eukaryotes. They polymerize DNA by an RNA template while its RNA subunit acts as a template for the synthesis of telomeric DNA. Moreover, the Telomerase Reverse Transcriptase subunit of telomerases is conserved in evolutionarily diverse organizations, such as protozoa, fungi and mammals. Proteins associated with telomerases also enhance the activity of catalytic subunits.

Analysis, Telomeres, Enzymes, Proteins

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Protein facilitation of group 1 intron splicing by assembly of the catalytic core and the 5'splice site domain

Article Abstract:

The yeast mitochondrial group I intron b15 goes through self splicing at high Mg ion concentration but needs the splicing factor CBP2 for reaction under physiological situations. Chemical accessibility and UV crosslinking show that self-processing is not fast because functional elements do not have the right position in active tertiary structure. The partition of labor between RNA and protein shows principles useful for complex ribonucleoprotein assemblies such as the spliceosome and ribosome.

Mitochondria, Yeast, Yeast (Food product)

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Beginning to understand the end of the chromosome

Article Abstract:

The regulation of telomerase by itself is discussed. The role of telomerase in cellular immortality and cancer is examined.

Science & research, Genetic regulation, Chromosomes, Telomerase

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