SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans

Article Abstract:

The gene sur-8 positively regulates Ras-mediated signal transduction during Caenorhabditis elegans vulval development. Reduction of sur-8 function suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations, while increase of sur-8 dosage enhances an activated ras mutaton. The sur-8 gene seems to act downstream of or in parallel to ras but upstream of raf. It encodes a conserved protein that is composed predominantly of leucine-rich repeats. The SUR-8 protein interacts directly with Ras but not with Ras(P34G) mutant protein.

Carrier proteins, Transport proteins, Caenorhabditis elegans, DNA binding proteins, Ras genes, Transduction, Transduction (Genetics)

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Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood

Article Abstract:

The germline stem cells maintain oogenesis in postnatal mouse ovaries. Study is conducted to show that adult mouse ovaries rapidly generate hundreds of oocytes, despite a small premeiotic germ cell pool and in considering the possibility of an extragonadal source of germ cells, germline markers are expressed in bone marrows.

Science & research, Mammals, Germ cells, Oogenesis

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