Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

Article Abstract:

Ski has been shown to be a part of the histone deacetylase (HDAC) complex. It is required for transcriptional repression mediated by the complex. Involvement of c-Ski in the HDAC complex indicates that HDAC complex function is important for oncogenesis. The nuclear hormone receptor corepressor (N-CoR/SMRT) complex, which comprises mSin3 and HDAC, mediates transcription repression through Mad and nuclear hormone receptors. In ski-deficient mouse embryos, the ornithine decarboxylase gene, the expression of which is usually repressed by Mad-Max, is express ectopically.

Japan, Research, Carcinogenesis, Thyroid hormones

---

The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron

Article Abstract:

A Caenorhabditis elegans gene, ham-2, links Hox gene patterning to migration of the HSN motor neuron. The Caenorhabditis elegans HSN motor neurons make it possible to do genetic analysis of neuronal development at the single-cell level. A zinc finger protein encoded by ham-2 acts downstream of egl-5 to direct HSN cell migration, which takes place early in differentiation. The EGL-43 zinc finger protein is also necessary for HSN migration. It is expressed in the HSN specifically during its migration.

Observations, Motor neurons, Cell differentiation, Caenorhabditis elegans

---

Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons

Article Abstract:

A novel factor called nasal embryonic leutinizing hormone-releasing hormone (LHRH) factor was found in a differential screen of migrating vs nonmigrating primary LHRH neurons. Nasal embryonic LHRH factor (NELF) is expressed in nervous system tissues in embryonic development, including olfactory sensory cells and LHRH cells. Study has shown that NELF acts as a common guidance molecule for olfactory axon projections and later in neurophilic migration of LHRH cells, directly or indirectly.

Statistical Data Included, Cell migration, Nose, Olfactory nerve, Luteinizing hormone

Similar abstracts:

• Abstracts: Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres
• Abstracts: Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Linker histone H1 regulates specific gene expression but not global transcription in vivo
• Abstracts: p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells
• Abstracts: Bird communities in two types of anthropogenic successional vegetation in central Amazonia. Effects of forest fragment size and successional stage on mixed-species bird flocks in southeastern Brazil
• Abstracts: RNA editing in kinetoplastid protozoa. Molecular genetics of the RNA polymerase II general transcriptional machinery

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.