Suppression of intestinal neoplasia by DNA hypomethylation

Article Abstract:

Inhibition of DNA methyltransferase activity by treating mice, heterozygous for DNA methyltransferase, with 5-aza-2'-deoxycytidine (5-aza-dC), results in a significant reduction in the number of intestinal tumors. Control animals had an average of 113 intestinal polyps, while this number was reduced to 2 polyps in heterozygous mice treated with 5-aza-dC. The inhibitor has a marked impact on the initiation stage, but no effect on the proliferation stages of carcinogenesis. The number of polyps was also reduced in mice with a mutant allele of the DNA methyltransferase gene. Results do not support DNA hypomethylation as a contributor to oncogenesis.

Research, Colorectal cancer, Tumors, Methylation, Methyltransferases

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HIF-1alpha is essential for myeloid cell-mediated inflammation

Article Abstract:

Results point out that activation of the hypoxia responsive transcription factor HIF-1alpha is required for myeloid cell infiltration and activation in vivo without the interference of VEGF. Further, HIF-1alpha regulates glycolytic capacity in myeloid cells and in its absence, the cellular ATP is decreased, impairment of myeloid cell aggregation and motility ensues, culminating in invasiveness and cell death.

United States, Netherlands, Germany, Physiological aspects, Inflammation, Genetic transcription, Transcription (Genetics), Cell aggregation, Cell motility

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Innate immunity gone awry: Linking microbial infections to chronic inflammation and cancer

Article Abstract:

Clinical and epidemiologic studies have suggested association between infectious agents and chronic inflammatory disorders and cancer. Better understanding of microbial pattern-recognition receptors and innate immune signaling pathways of the hosts helps elucidate connection between microbial infection and chronic disease.

Chronic diseases, Genetic aspects, Genetic research

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