TGF-beta-stimulated cooperation of Smad proteins with the coactivators CBP/p300

Article Abstract:

TGF-beta and activin bring on phosphorylation/activation of Smad2 and Smad3 by a poorly understood mechanism. TGF-beta receptor phosphorylation of Smad3 brings on interaction with the paralogous coactivators CBP and p300. CBP/p300 binding to non-phosphorylated Smad3 or its oligomerization partner Smad4 is regulated in a negative way by Smad-intramolecular interactions. CBP/p300 are important in activin/TGF-beta signaling. They may mediate antioncogenic activities of Smad2 and Smad4.

Genetic regulation, Genetic transcription, Transcription (Genetics)

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Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

Article Abstract:

Research shows that antigen receptor activation plays an important role in transcription factor processes. Activation results in BCL-6 phosphorylation through mitogen-activated protein kinase, which degrades BCL-6 through the ubiquitin/proteasome pathway. This finding indicates that antibody response and B-cell differentiation can be controlled via the activation process, possibly preventing B-cell lymphoma pathogenesis.

United States, Antigen receptors, T cell, T cell antigen receptors, Chromosomal proteins, Antibodies

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Not just scaffolding: plectin regulates actin dynamics in cultured cells

Article Abstract:

Plectin plays a significant part in regulating cell processes involving actin filament dynamics. Already established as a scaffolding protein of cellular cytoskeleton, plectin has been seen to interact with G-actin and associates with actin stress fibers in living cells. Beyond its importance in the mechanical integrity of skin and heart tissues, plectin is essential to fibroblast and astroglial cell formation.

Analysis, Actin, Cytoskeleton, Cell research, Cytological research, Fibroblasts

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