Relief of gene repression by Torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning

Article Abstract:

The role of capicua in Drosophila dorsoventral and terminal patterning is discussed relative to relief of gene repression by Torso (Tor) receptor tyrosine kinase (RTK) signaling. A new gene, cic, one which acts as a repressor of terminal genes regulated by the Tor pathway and mediates repression along the dorsoventral axis has been identified. The gene also encodes an HMG-box transcription factor that interacts with Gro in vitro. Evidence that Tor signaling regulates terminal patterning by inactivating Cic at the embryo poles has been found. Cic-like proteins may act as repressors regulated by RTK signaling in other organisms.

Germany, Usage, Growth factors, Cellular signal transduction, Gene expression, Embryology, Experimental, Embryological research, Protein tyrosine kinase, Protein-tyrosine kinase

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Specific tracheal migration is mediated by complementary expression of cell surface proteins

Article Abstract:

Specific tracheal migration has been found to be mediated by complementary expression of cell surface proteins. The role of cell adhesion receptors of the integrin family in the definition of a migratory pathway in Drosophila has been studied.

United Kingdom, Statistical Data Included, Molecular biology, Cell membranes, Cell adhesion, Cell migration

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The RhoGAP corssveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination

Article Abstract:

Tracheal cell behavior at vagination is described and it is shown that it is associated with, and requires, a distinct recruitment of Myosin II to the apical surface of cells at the invaginating edger. The results identify a developmental pathway linking cell fate genes and cell signaling pathways to intracellular modifications during tracheal cell invagination.

Genetic research, Tracheal diseases

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