The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells

Article Abstract:

The basic helix-loop-helix protein BETA2 associates in a functional way with p300, coactivator, in order to activate transcription of the secretin gene and the gene encoding the cyclin-dependent kinase inhibitor p21. Cell cycle arrest and apoptosis are brought on by overexpression of BETA2 in cell lines. Normally quiescent cells go back into the cell cycle in the small intestine of mice without BETA2. It may coordinate transcriptional activation of cell number regulation, secretin genes, and cell cycle conclusion. This is perhaps one of the first examples of a transcription factor that controls ultimate differentiation of cells in intestinal epithelium.

Genetic transcription, Transcription (Genetics), Molecular genetics, Intestinal mucosa, Endocrinology, Experimental

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Cold shock and regulation of surface protein trafficiking convey sensitivization to inducers of stage differentiation in Trypanosoma brucei

Article Abstract:

It is shown that a cold shock of deltaT>15degrees Celsius is sufficient to reversibly induce high-level expression of the insect stage-specific EP gene in the mammalian bloodstream stages of Trypanosoma brucei. A hierarchical model of three events that regulate differentiation after transmission to the tsetse: sensing the temperature change, surface access of a putative receptor, and sensing of a chemical cue is presented.

Science & research, Protozoan diseases

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A major surface glycoprotein of Trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia

Article Abstract:

In Trypanosoma brucei a major surface glycoprotein is expressed transiently in development. It can be regulated by glycerol or hypoxia after transcription. It has been shown that GPEET expression in the tsetse fly, which transmits T. brucei, is a transient event in establishment of midgut infections. Developmental regulation of the GPEET mRNA is mediated by the BPEET3' UTR.

Switzerland, Belgium, Physiological aspects, Glycoproteins, Hypoxia, Anoxia, Cytochemistry, Glycerol, Tsetse-flies, Tsetse flies

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