The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

Article Abstract:

The CCR3 and CCR5 members of the chemokine receptor family play major roles in early events in HIV-1 infection. The expression of CCR5 with CD4 makes most cell lines that are resistant to primary HIV-infection susceptible. The expression of CCR3 increases infection by a smaller subset of primary viruses compared to CCR5. The binding of the CCR3 ligand, eotaxin, suppresses infection. CCR3 and CCR5 assist virus binding to target cell and/or membrane fusion.

HIV infection, HIV infections, Ligand binding (Biochemistry)

---

Protein-protein communication: structural model of the repression complex formed by CytR and the global regulator CRP

Article Abstract:

A study was conducted on structural model of the repression complex formed by CytR. The research utilized two mutagenesis strategies namely molecular modelling and in vitro binding assays to determine the cognate site in CytR. Results reveal that the structure of the CRP-DNA (cAMP receptor protein) reflects that the amino acids exhibiting a CRP phenotype is in close proximity to the surface of the CRP.

Cyclic adenylic acid, Cyclic adenosine monophosphate, Mutagenesis

---

CD46 is a cellular receptor for human herpesvirus 6

Article Abstract:

Results demonstrate that CD46 serves as a human cellular receptor for human herpesvirus 6 (HHV-6) groups A and B. Data also indicate that non human cells resistant to HHV-6 show susceptibility to HHV-6 when human CD46 is expressed in them.

Italy, United States, Herpesviruses, Cellular immunity

Similar abstracts:

• Abstracts: Absconding with the chaperone: essential cyclophilin-Gag interaction in HIV-1 virions. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B
• Abstracts: Bacterial outer membrane vesicles and the host-pathogen interaction. part 2 Critical and distinct roles for key RET tyrosine docking sites in renal development
• Abstracts: Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry. Viral latency in HIV disease
• Abstracts: Geographic, temporal, and age-specific variation in diets of glaucous gulls in western Alaska. Technique-dependent biases in determination of diet composition: an example with ring-billed gulls
• Abstracts: Bacterial alginate biosynthesis - recent progress and future prospects

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.