The cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

Article Abstract:

A study on the cloning of the CSA cDNA, which can encode a WD protein indicates that the products of the CSA and CSB genes are involved in transcription. The cloned CSB gene encodes a member of a protein family that includes the yeast Snf2 protein a component of the transcriptional regulator Swi/Snf. It is also found that CSA protein associates with CSB protein and with p44 protein, a subunit of the human RNA polymerase II transcription factor IIH.

Proteins, RNA polymerases, Heredity

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UV irradiation triggers ubiquitin-dependent degradation of p21(sup)WAF1 to promote DNA repair

Article Abstract:

Results show that the protein p21 responds to DNA damage and its UV-induced degradation is required for optimal DNA repair. Further, the UV degradation of p21 protein switches to ubiquitin/Skp2-dependent proteasome pathway upon UV irradiation. p21 protein is a cyclin-dependent kinase inhibitor.

Science & research, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Enzyme Inhibitors, Physiological aspects, DNA repair, DNA damage, Radiobiology

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Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for cockayne syndrome

Article Abstract:

Research has been conducted on the oxidative lesion transcription-coupled repair. Results indicate the strand-specific removal of oxo-guanine and thymine glycol in normal human cells.

United States, Statistical Data Included, Cell research, Cytological research, Oxidation-reduction reaction, Guanine, Oxidation reduction reactions, Ethylene glycol

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