The exosome: a conserved eukaryotic RNA processing complex containing multiple 3' - 5' exoribonucleases
Article Abstract:
Caspases directly or indirectly stimulates the active forms through direct ligation of receptors at cell surface. Irreparable damage to the genome caused by mutagens, drugs that inhibit DNA repair, or ionizing radiation is mediated by the same executioner caspases. The subsequent events progress through a cascading pathway that is regulated by members of the Bcl2/Bax family, resulting in the release of proapoptotic factors from mitochondria.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Maturation and intranuclear transport of pre-ribosomes requires Noc proteins
Article Abstract:
Research has been conducted on the intranuclear ribosomal precursor particle movement. The effect of the Noc protein dynamic interaction on this movement has been investigated and the results indicate that this interaction may represent a prerequisite for the proper pre-ribosome maturation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
RNA degradation by the exosome is promoted but a nuclear polyadenylation complex
Article Abstract:
The exosome complex of 3'-5' exonucleases participates in RNA maturation and quality control and can rapidly degrade RNA-protein complexes in vivo. However, the purified exosome showed weak in vitro activity indicating that rapid RNA degradation requires activating cofactors.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock
- Abstracts: The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. In vivo analysis of Drosophila bicoid mRNA localization reveals a novel microtubule-dependent axis specification pathway
- Abstracts: The Drosophila clock gene double-time encodes a protein closely related to human casein kinase I epsilon. Double-time is a novel Drosophila clock gene that regulates period protein accumulation
- Abstracts: Smoothened mutants reveal reduntant roles for Shh and Inn signaling including regulation of L/R asymmetry by the mouse node
- Abstracts: Major gene effects during weed evolution: phenotypic characters cosegregate with alleles at the Ray Floret Locus in Senecio vulgaris L. (Asteraceae)