Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

Article Abstract:

The role of BETA2/NeuroD1, a bHLH transcription factor expressed in development in the mammalian pancreas and in many central/peripheral nervous systems places in development of the vestibular and auditory systems, has been investigated. Mice with a null mutation have behavior abnormalities that suggest an inner ear defect. Defects can be explained by a major lack of sensory neurons in the cochlear-vestibular ganglion (CVG). BETA2/NeuroD1 is the first gene shown to regulate neuronal and sensory cell development in both the cochlear and vestibular systems.

Genetic transcription, Transcription (Genetics), Neurons, Developmental neurology, Cytogenetics, Labyrinth (Ear), Ganglia, Nerves, Cranial, Cranial nerves

---

COUP-TFI: an intrinsic factor for early rationalization of the neocortex

Article Abstract:

COUP-TFI, an orphan member of the nuclear-receptor superfamily, has been identified as a regulatory factor for early neocortical regionalization in study using mutant mice. The spatial and temporal expression pattern of COUP-TFI indicates a possible role in specification of the neocortex and in keeping cortical identity intact, perhaps working with Pax6 and Emx2, intrinsic factors.

Statistical Data Included, Cytochemistry, Developmental cytology, Neocortex

---

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development

Article Abstract:

The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is necessary for heart development and angiogenesis. F1 heterozygotes were intercrossed to generate homozygotes in an effort to determine the physiological results of deleting COUP-TFII. At weaning no homozygotes were found in initial analysis of 132 F2 offspring. More analysis of heterozygous intercrossings found no COUP-TFII homozygotes at birth. The homozygous mutation at the locus is thus lethal for the embryo, the result of defective heart development and angiogenesis. COUO-TFII is in the steroid/thyroid hormone receptor superfamily and may be becessary fo bidirectional signaling between endothelial and mesechymal comparments required for heart development and angiogenesis.

Abnormalities, Heart, Developmental biology, Neovascularization, Gene expression, Cardiovascular abnormalities

Similar abstracts:

• Abstracts: Combinatorial roles of the nuclear receptor corepressor in transcription and development. Identification of a regulated pathway for nuclear pre-mRNA turnover
• Abstracts: The EGF receptor provides an essential survivial signal for SOS-dependent skin tumor development. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest
• Abstracts: LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic. Linking colorectal cancer to Wnt signaling
• Abstracts: Intron polymorphism (EPIC-PCR) reveals phylogeographic structure of Zacco platypus in China: A possible target for aquaculture development
• Abstracts: Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.