The response of human epithelial cells to TNF involves an inducible autocrine cascade

Article Abstract:

An experimental and computational analysis of crosstalk between prodeath (Tumor necrosis factor) TNF and prosurvival growth factors in human epithelial cells are reported. The findings suggest that the extent of crosstalk between autocrine and intracellular networks and their relative physiological importance might depend on cell type and stimulus.

United States, Autocrine mechanisms, Tumor necrosis factor, Tumour necrosis factor

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A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

Article Abstract:

A network of protein interactions that centre around the Cdc42 RhoGAP Rich1 and organize apical polarity in MDCK epithelial cells is identified. Rich1 and Amot maintain tight junctions (TJ) integrity by the coordinate regulation of Cdc42 and by linking specific components of the TJ to intracellular protein trafficking.

Genetic research

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Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD

Article Abstract:

A study is conducted to develop intestinal epithelial cell lines in which inducible STRAD activates LKB1. The conclusion states that LKB1 can induce complete polarity in intestinal epithelial cells.

Polarity (Biology)

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