The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo

Article Abstract:

Loss- and gain-of-function alleles are developed to detect the role of Pax3 in myogenesis with the help of a sequence encoding the oncogenic fusion protein PAX3-FKHR into the Pax3 locus. This allele offers a move towards the molecular and cellular analysis of the role of Pax3 and of its target genes in vivo.

Genetic transcription, Transcription (Genetics), Phenotype, Phenotypes, Myogenesis, Oncology

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A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb

Article Abstract:

The molecular control of myogenesis in progenitor cells derived from the hypaxial somite is addressed. An allele of Pax3 encoding a Pax3-engrailed fusion protein that acts as a transcriptional repressor is developed.

Analysis, DNA binding proteins, Muscle proteins

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Divergent functions of murine Pax3 and Pax7 in limb muscle development

Article Abstract:

Mouse mutations for Pax3 and Pax7 have very different consequences despite partially overlapping expression domains. Pax3/7 genes are fulfilled and the details of their functions are discussed.

Gene expression

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