Transcription occurs in pulses in muscle fibers

Article Abstract:

In a myofiber nucleus, some muscle loci are not transcriptionally active at any one time and loci are independently regulated. Because the nuclei in a myofiber have cytoplasm in common, the phenomenon is remarkable. Endogenous muscle-specific and housekeeping genes and transgenes are regulated by the same means. In spite of the protein composition of the contractile mechanism in the length of the fiber, the loci that encode the structure are not transcribed continuously. The number of active loci for one gene changes at various stages. Potentially it reflects the growth status of the fiber. In muscle fibers, transcription takes place in pulses.

Genetic aspects, Observations, Genetic regulation, Genetic transcription, Transcription (Genetics), Muscle cells, Muscle proteins

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Testosterone treatment results in quiescent satellite cells being activated and recruited into cell cycle in rat levator ani muscle

Article Abstract:

A study was conducted to determine whether satellite cells treated with testosterone can undergo DNA synthesis by incorporating (3H)thymidine and whether they can fuse with mature myofibers. Autoradiographic study of muscle cells from 30-day old female rats injected with testosterone in different hours after treatment revealed an increase in myonuclei number in muscles treated between the 32nd hour and the 34th hour. This suggests that cell proliferation occurs in the 33rd hour after treatment because of the increased number of myonuclei observed.

Physiological aspects, Cell cycle, Rats

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MusTRD can regulate postnatal fiber-specific expression

Article Abstract:

Regulation of slow fiber-specific genes by muscle TF II-In like repeat domain 1?1 gene, using transgenic mice studies, is presented.

Australia, Science & research, Usage, Genetically modified mice

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