Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in aplysia

Article Abstract:

Immunological techniques, supplemented with nucleic acid analysis and electrophysiology, were used to investigate the mechanics of short- and long-term facilitation of synapses in the nerve cells of Aplysia. The results demonstrated that the neuron-specific ubiquitin C-terminal hydrolase immediate-early gene encodes an enzyme which associates with the proteasome and increases its proteolytic activity. Such enhanced catalytic function was identified to be essential for long-term facilitation. It was further shown that inhibiting the expression of the hydrolase blocks induction of long-term but not short-term facilitation.

Research, Analysis, Usage, Genetic transcription, Transcription (Genetics), Proteolysis, Ubiquitin, Enzymatic analysis, Aplysia, Western immunoblotting, Western blot

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A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in Aplysia

Article Abstract:

Research shows that a neuron-specific isoform of cytoplasmic polyadenylation elelment binding protein (CPEB) in Aplysia regulates the synaptic protein synthesis in an activity-dependent manner. Data indicate that CPEB protein is upregulated at activated synapses and is involved in the maintenance of long-term facilitation.

United States, Physiological aspects, Protein synthesis, Cellular control mechanisms, Cell regulation, Protein biosynthesis, Neuroplasticity, Long-term memory

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