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Angiogenic zip code

Article Abstract:

Renata Pasqualiini and a team of researchers have used phage panning to identify a unique peptide, only ten residues long that not only selectively targets angiogenic blood vessels but inhibits the matrix metalloproteinases (MMPs) MMP-2 and MMP-9. When injected into mice the peptide thwarts both growth and invasion of the tumor.

Author: Folkman, Judah
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 1999
Anticancer Drugs, Antineoplastic agents

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Therapeutic peptides revisited: after a roller coaster ride of successes and failures, new discovery technologies and advances in manufacturing promise a brighter future for peptides in human therapy

Article Abstract:

Forty years after Nobel laureate Bruce Merfield first explained resin-based peptide synthesis, unusually few peptide products have made it to the clinic. Cost and reliable manufacture of peptides remain stumbling blocks to profitable commercialization.

Author: Latham, Peter W.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 1999

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Multiphoton-evoked color change of DsRed as an optical highlighter for cellular and subcellular labeling

Article Abstract:

A recently cloned red fluorescent protein, DsRed, has stimulated great interest as an expression tracer and fusion partner for multicolor imaging.

Author: Marchant, Jonathan S. et al
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2001
Pharmaceutical preparations

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Subjects list: United States, Protein preparations
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