(2 + 2) photocycloaddition/fragmentation strategies for the synthesis of natural and unnatural products

Article Abstract:

The (2 + 2) photocycloaddition/fragmentation of dioxinones and vinylogous amides result in the preparation of bicycloalkanes with trans intrabridgehead stereochemistry and tricyclic nucleus of the taxane diterpenes maintaining the stereoselectivity. These reaction procedures are applied to generate active biological analogs of the protein kinase C activating compound ingenol. Mesembrine and aspidosperma alkaloid are obtained by the vinylogous amide photocycloaddition/retro-Mannich fragmentation/Mannich closure series.

Observations, Stereochemistry

---

Ruthenium-catalyzed reactions for organic synthesis

Article Abstract:

Research was conducted to examine ruthenium-catalyzed reactions for organic synthesis. Several ruthenium complexes were prepared and divided into five groups depending on their supporting ligands, namely, oxo, carbonyl, tertiary phosphines, cyclopentadienyl and arenes and dienes. A range of fields of organic syntheses related to oxidation, reduction, isomerization, carbon-carbon bond formation and miscellaneous nucleophilic and electrophilic reactions were also investigated.

Catalysis, Metal catalysts, Ruthenium

---

Synthesis of strychnine

Article Abstract:

Strychnine is a natural product produced in the seeds and bark of Strychnos nux vomica and possesses pharmacological and extremely toxic properties. Structurally, it is very complex and the review summarizes eight synthetic approaches that have been developed in the past decade with detailed account on three of the enantiospecific syntheses of (-)-strychnine.

Spain, Statistical Data Included, Usage, Reactivity (Chemistry), Aldehydes, Enantiomers, Strychnine, Diels-Alder reaction

Similar abstracts:

• Abstracts: Total synthesis of oxyacyclic macrodiolide natural products. Total synthesis of alpha-pyrone meroterpenoids, novel bioactive microbial metabolites
• Abstracts: (pi-allyl)Tricarbonyliron lactone complexes in organic synthesis: a useful and conceptually unusual route to lactones and lactams
• Abstracts: Applications of sulfoxides to asymmetric synthesis of biologically active compounds. Acyclic stereocontrol induced by allylic alkoxy groups. Synthetic applications of stereoselective dihydroxylation in natural product synthesis
• Abstracts: Quebrachitol: a versatile building block in the construction of naturally occurring bioactive materials. Fluorinated ylides and related compounds
• Abstracts: AIDS-driven nucleoside chemistry. BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Syntheses of nucleoside triphosphates

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.