Comparative genomics and evolution of alternative splicing: the pessimists' science

Article Abstract:

Various programs related to bioinformatics of splicing and comparative genomics of alternative splicing which failed to identify splicing enhancers and silencers and reliably predict the exon-intron structure of a constitutively spliced genes are reviewed.

Analysis, Genetic aspects, Eukaryotes, RNA splicing, Exon (Molecular genetics), Exons (Molecular genetics), Computational biology

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Perspectives on chemistry and therapeutic applications of locked nucleic acid (LNA)

Article Abstract:

Various chemical perspectives and the therapeutic applications of the locked nucleic acid (LNA) and its oligonucleotides are discussed. LNA is found to be highly beneficial in the biotechnology and medical fields.

Biological Product (except Diagnostic) Manufacturing, Drugs, Nucleic Acids, Chemical properties, DNA microarrays

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