Differential display PCR: a new age in nutrition investigation

Article Abstract:

The use of differential display polymerase chain reaction (PCR) can provide further details of nutritional deficiencies via gene amplification. The new PCR technology is helping nutritionists to locate cell adaptations in response to nutritional effects, such as copper deficiencies, ferritin overexpression, and obesity-related neuropeptide expression. Such animal models are providing exciting preliminary results until the advent of human clinical trials.

Diagnosis, Genetic aspects, Polymerase chain reaction, Nutritionally induced diseases, Nutrition disorders, Deficiency diseases

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Lipoprotein[a]: a predictor of atherosclerotic disease

Article Abstract:

Lipoprotein[a] (Lp[a]) seems to promote the development of atherosclerosis. Since 1963, elevated Lp[a] levels have been linked to an increased risk of heart attack, coronary heart disease and stroke. Lp[a] is a type of low-density lipoprotein (LDL) that contains the apo[a] protein. Apo[a] bears a striking resemblance to plasminogen and may prevent plasmin from dissolving blood clots. Consequently, it could enlarge fatty plaques in arteries.

Cardiovascular diseases, Risk factors, Physiological aspects, Atherosclerosis, Lipoprotein A

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The iron-copper connection: the link to ceruloplasmin grows stronger

Article Abstract:

Ceruloplasmin's importance for iron metabolism and tissue distribution in human is shown by a rare genetic defect in ceruloplasmin biosynthesis. Huge accumulations of iron in the liver and brain are related to retinal degeneration and diabetes. Ceruloplasmin synthesis from its mRNA is due to genetic mutation. A study shows that aceruloplasmia is concomitant with low serum iron and high tissue stores.

Analysis, Diabetes, Diabetes mellitus, Iron in the body, Iron (Nutrient), Retinal degeneration

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