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A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease

Article Abstract:

Low-molecular-weight heparin appears to lead to a lower incidence of heart attack or death in patients with unstable angina compared to unfractionated heparin. Researchers randomly assigned 3,171 patients with unstable angina to receive twice daily subcutaneous injections of low-molecular-weight heparin or continuous intravenous unfractionated heparin. At 14 and 30 days, the incidence of heart attack, death or recurring angina was lower in the patients who received low-molecular-weight heparin. However, they had a slightly higher risk of bleeding.

Author: Califf, Robert M., Cohen, Marc, Turpie, Alexander G.G., Langer, Anatoly, Demers, Christine, Fox, Keith A.A., Gurfinkel, Enrique P., Fromell, Gregg J., Goodman, Shaun, Premmereur, Jerome, Bigonzi, Frederique
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1997
Prevention, Unstable angina, Heart attack, Heparin

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Prasugrel versus clopidogrel in patients with acute coronary syndromes

Article Abstract:

The comparison results of a novel potent thienopyridine (prasugrel) with the standard thienopyridine (clopidogrel) in patients with acute coronary syndromes scheduled to have a coronary intervention are presented. Prasugrel therapy was found to be associated with significantly reduced rates of ischemic events, including stent thrombosis, but with an increased risk of major bleeding.

Author: Antman, Elliott M., Gibson, C. Michael, McCabe, Carolyn H., Braunwald, Eugene, Montalescot, Gilles, Ardissino, Diego, Wiviott, Stephen D., Murphy, Sabina A., Ruzyllo, Witold, Gottlieb, Shmuel, Neumann, Franz-Joseph, de Servi, Stefano, Riesmeyer, Jeffrey, Weerakkody, Govinda
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
Complications and side effects, Coronary heart disease, Dosage and administration, Clopidogrel, Clinical report

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Enoxaparin versus unfractionated heparin in elective percutaneous coronary intervention

Article Abstract:

The safety of enoxaparin as compared with that of unfractionated heparin in elective percutaneous coronary intervention (PCI), is accessed The results indicate that, depending on the dose, intravenous enoxaparin is associated with bleeding rates that are similar to or lower than those with unfractionated heparin in patients undergoing elective PCI.

Author: Harrington, Robert A., White, Harvey D., Cohen, Marc, Montalescot, Gilles, King, Spencer B., III, Chiariello, Massimo, Steg, P. Gabriel, Steinhubl, Steven R., Gallo, Richard, Aylward, Philip E.G., Bode, Christoph, Desmet, Walter J., Macaya, Carlos
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
Methods, Cardiac patients, Angioplasty, Enoxaparin

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Subjects list: Health aspects, Drug therapy, United States
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