A promoter mutation that increases transcription of the tumor necrosis factor-alpha gene is not associated with preterm delivery

Article Abstract:

Variations of the tumor necrosis factor-alpha (TNF-alpha) gene do not appear to predispose women to premature labor despite associations with increased TNF-alpha levels during premature labor. Tests of TNF-alpha gene variations were performed on 203 women who delivered prematurely and their premature infants. Results were compared with published genetic frequencies. The T1 and T2 genetic variation frequencies seen in these mothers and infants were similar to those found in the general population.

Health aspects, Gene mutations, Gene mutation, Premature birth, Tumor necrosis factor

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Hypervolemia of pregnancy is not maintained in mice chronically overexpressing angiotensinogen

Article Abstract:

Reduced hypervolemia of pregnancy is seen early in the second trimester in women who develop pre-eclampsia and a study is carried out to see if increased angiotensinogen expression is sufficient to cause failed hypervolemia. It is concluded that chronically increased angiotensinogen expression is sufficient to cause failed hypervolemia of pregnancy.

Care and treatment, Risk factors, Preeclampsia, Pregnancy, Complications of, Pregnancy complications, Clinical report

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Genetic expression by fetal chorionic villi during the first trimester of human gestation

Article Abstract:

Researchers have identified 17 genes from fetal membranes that do not match any known genetic sequence. One of the genes is expressed in fetal brain, lung, liver, and kidney and may therefore play a major role in fetal development.

Fetus

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