A protective gene for graft-versus-host disease

Article Abstract:

A gene variation that produces high amounts of interleukin-10 may protect some stem cell transplant recipients from developing a serious complication of transplantation called graft-versus-host disease (GVHD). Interleukin-10 suppresses the immune response and helps the immune system tolerate the transplant. A 2003 study confirmed this effect in patients who received an HLA-identical transplant from a relative. Further research is needed to determine if it can occur between unrelated donors and recipients.

Health aspects, Prevention, Complications and side effects, Genetic aspects, Hematopoietic stem cell transplantation, Graft versus host reaction, Graft vs. host disease, Interleukin-10

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Sick chaperones, cellular stress, and disease

Article Abstract:

Systems of proteins known as molecular chaperones help to preserve a total set of functionally efficient proteins in cells during injury or anxiety. A study describes the contribution of defective chaperones to aging and many other diseases.

United States, Science & research, Care and treatment, Research, Diagnosis, Risk factors, Anxiety, Molecular chaperones

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