A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord
Article Abstract:
A study was conducted to examine whether neutralizing Sema3A by administering SM-216289 to the injured spinal cord could create a more permissive environment for axonal regeneration in vivo. Sema3A is essential for the inhibition of axonal regeneration and other regenerative responses after spinal cord injury (SCI) and Sema3A inhibitors could be used in the treatment of human SCI patients.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Cell-based tests tackle predicting safety of antibody drugs
Article Abstract:
The European Center for the Validation of Alternative Methods (EVCAM) in March 2006 approved six new toxicology screens based on cultures of human cells that would help predict the safety of antibody drugs. The new techniques improve on two expensive present methods, namely the Limulus assay and testing on rabbits, and might eventually replace the existing technology.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Electrical impulses recharge spinal cord injury research
Article Abstract:
A study conducted at the Baltimore-based Kennedy Krieger Institute revealed that exercise could improve sensory and motor function long after the initial injury. The study concluded that of the restorative group, 40% regained some motor function such as the ability to walk without a walker or better bladder control as compared with only 4% in the stretching group.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Case 35-2004: A 68-year-old man with end-stage renal disease and thickening of the skin. Salt wasting and deafness resulting from mutations in two chloride channels
- Abstracts: Routine vs. selective invasive strategies in patients with acute coronary syndromes: A collaborative meta-analysis of randomized trials
- Abstracts: Erlotinib in lung cancer: Molecular and clinical predictors of outcome. Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer
- Abstracts: Rectoceles and the anatomy of the posterior vaginal wall: Revisited. Is previous cesarean section a risk for incidental cystotomy at the time of hysterectomy? A case -controlled study
- Abstracts: Universities offer animal rights courses. Seeking the ghost of worms past. Blood pressure vaccine shot down by safety concerns