A trial of three regimens for primary amyloidosis: colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicine

Article Abstract:

A combination of melphalan, colchicine and prednisolone appear to be more effective in treating amyloidosis than colchicine alone. Amyloidosis is characterized by an abnormal deposition of proteins in various organs. Researchers randomly assigned 220 patients with amyloidosis to take either colchicine alone, melphalan and prednisone or all three drugs. The two drug combinations more than doubled the average survival rate compared to colchicine alone. Those who experienced a drop in blood levels of the protein had longer survival rates.

Evaluation, Drug therapy, Amyloidosis, Prednisone, Melphalan, Colchicine

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Multiple myeloma

Article Abstract:

Multiple myeloma is a plasma-cell neoplasm that is characterized by skeletal destruction, renal failure, anemia and hypercalcemia. The improved understanding of myeloma-associated bone disease has led to the use of prophylactic bisphosphonate therapy.

Science & research, Care and treatment, Research, Thalidomide

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Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma

Article Abstract:

An attempt is made to study the clinical progression of multiple myeloma, its prognosis, the outcome of the disease and follow-up procedures.

Patient outcomes, Prognosis, Clinical report

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