Monoamine transporter gene polymorphisms and antidepressant response in Koreans with late-life depression

Article Abstract:

A study was conducted among Koreans with late-life depression to determine whether antidepressant responses to selective serotonin reuptake inhibitors (SSRIs) or norepinephrine reuptake inhibitors (NRIs) are associated with genetic polymorphisms of the corresponding monoamine transporters. Results suggested that monoamine transporter gene polymorphisms are associated with response to antidepressants with homologous monoamine transporter targets, thus enabling refined pharmacogenetic selection of antidepression treatment.

Care and treatment, Depression, Mental, Depression (Mood disorder), Genetic polymorphisms, Koreans

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Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial

Article Abstract:

A study to ascertain the effectiveness of using behavioral treatment along with venlafaxine for adolescents with continued depression not responding to treatment with selective serotonin reuptake inhibitor (SSRI) is conducted. Results reveal that the combined therapy yielded improved results and a change to another SSRI produced the same results as when using venlafaxine.

United States, Youth, Psychological aspects, Evaluation, Patient outcomes, Clinical trials, Drug therapy, Teenagers, Dosage and administration, Serotonin uptake inhibitors, Selective serotonin reuptake inhibitors, Psychotherapy, Depression in adolescence, Adolescent depression, Venlafaxine

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Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: A meta-analysis of randomized controlled trials

Article Abstract:

The efficacy and risk of reported suicidal ideation/suicide attempt of antidepressants for treatment of pediatric major depressive disorder (MDD), obsessive-compulsive disorder (OCD) and non-OCD) anxiety disorders are assessed. The results have shown that the effects are strongest in non-OCD anxiety disorders, intermediate in OCD and more modest in MDD.

Complications and side effects, Risk factors, Child psychiatry, Suicidal ideation

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