Clinical evaluation of atypical glandular cells of undetermined significance

Article Abstract:

About one-third of women whose Pap test shows atypical glandular cells of undetermined significance may have cervical intraepithelial neoplasia (CIN), according to a study of 492 women. CIN is considered to be a precursor of cervical cancer.

Medical examination, Vaginal smears

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Atypical glandular cells of undetermined significance: a five-year retrospective histopathologic study

Article Abstract:

Women whose Pap smear reveals atypical glandular cells of undetermined significance (AGUS) should be followed up every four to six months. In a study of 199 women with AGUS on Pap smear, 32% had precancerous or cancerous tissue. Among the 133 women who had no pathologic tissue on the first Pap smear, 25 developed pathologic tissue during the five-year follow-up and two developed cervical cancer. The American Society for Colposcopy and Cervical Pathology recommends regular exams and cervical biopsies for women with AGUS.

Analysis, Pap test

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Atypical glandular cells of undetermined significance in cervical cytologic findings

Article Abstract:

Many women with atypical glandular cells of undetermined significance may have a precursor of cervical cancer called cervical intraepithelial neoplasia (CIN). Atypical glandular cells of undetermined significance are an abnormality seen on a Pap smear that is not normal but not cancerous. An analysis of 76,018 Pap smears showed that the frequency of atypical glandular cells of undetermined significance was about 0.2%. Of 80 women with atypical glandular cells of undetermined significance, 45% had significant cervical abnormalities and six had CIN.

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