BRCA1 mutations and breast cancer in the general population: analyses in women before age 35 years and in women before age 45 years with first-degree family history

Article Abstract:

It may be difficult to determine which groups of American women should be screened for mutations in the BRCA1 gene. These mutations have been linked to an increased risk of breast and ovarian cancer. Researchers tested two groups of women who might be considered at high risk of having a mutation: 193 women diagnosed with breast cancer before the age of 35 and 208 women diagnosed before the age of 45 who had a family history of breast cancer. Only 6% of the first group and 7% of the second group had a BRCA1 mutation. Women with more than one relative with breast cancer or relatives with ovarian cancer were more likely to have a mutation.

Testing, Gene mutations, Gene mutation, Genetic aspects

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Trends in incidence rates of invasive lobular and ductal breast carcinoma

Article Abstract:

The increased risk of breast cancer caused by some types of hormone replacement therapy appears to be limited to invasive lobular breast cancer, according to researchers who analyzed data from nine cancer registries between 1987 and 1999. During that time, invasive lobular breast cancer increased from 9% of all breast cancer cases to 16% of all breast cancer cases. This type of cancer is not common, but is more difficult to detect on mammograms.

Labor Distribution by Employer, Statistics

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Relationship between long durations and different regimens of hormone therapy and risk of breast cancer

Article Abstract:

Hormone replacement therapy consisting of estrogen and progestin may increase a woman's risk of breast cancer, according to a study of 975 women. They had a higher risk of developing invasive lobular breast cancer than non-users, especially if they used hormone replacement therapy for more than five years. This was true whether they took the progestin sequentially or continually.

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